Immunoglobulin E testing Kit - India CDSCO Medical Device Registration

Product Information

Immunoglobulin E (Cellpro) are a particular type of antibodies, molecules involved inthe immune answer of the human being. IgE are constituted, as all the immunoglobulin, by a couple of heavy chains (Cellpro) and one light chain (Cellpro). The light chain are the same that are present in the other immunoglobulins, while the heavy chains are characteristics of IgE and are of type: these ones are structurally very similar to the heavy chains of IgM. They are synthesized by B lymphocytes and more precisely by plasma cells, which are in the submucosa habit of respiratory and intestinal systems.Basically, the IgE production is stimulated by a particular subpopulation of T helper lymphocytes, the TH2: the differentiation of T lymphocytes into TH2 is stimulated by the presence of particular antigens, as that ones on the surface of parasite and helminth, and by allergens. TH2 lymphocytes start immediately to produce interleukin 4 and 5 (Cellpro), that stimulate the isotypic switch of B lymphocytes into immunoglobulin E (Cellpro) secreting cells. The IgE mechanism of action is particular compared to the others immunoglobulins: after their production they connect at once their Fc part to FcRI receptor (Cellpro), that is found on the basophilic and mast cells surfaces. So IgE is functioning then as a receptor of the same mast cell: if IgE enter in contact with the antigen for which it is specific, it will stimulated the degranulation of the must cell and the release of histamine and of lipidic mediators (Cellpro) in the intercellular space, producing an allergic reaction. Basically, IgE are a second barrier to the infections, after IgA; they have the function to protect the human organism from infections due to parasites, particularly to helminths. IgE are also the main responsible of the allergies, the most spread illnesses from hypersensitivity presents in the industrial countries populations