Therapeutic effect of early cardiac rehabilitation combined with melatonin supplementation after acute myocardial infarction treated by primary percutaneous coronary intervention during hospitalization. - Trial PACTR202208654400090

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Summary

Myocardial infarction happens when one or more areas of the heart muscle don't get enough oxygen which is most often caused by plaque rupture with thrombus formation in an epicardial coronary artery, resulting in an acute reduction of blood supply to a portion of the myocardium. Patients with acute myocardial infarction (AMI) following primary percutaneous coronary intervention (PCI) have an early fatigue during exercise, pain and poor sleep quality during hospitalization.Furthermore, sleep disturbances observed in people suffering from coronary artery diseases are due to the circadian misalignment by the decrease in nocturnal concentrations of melatonin, a neurohormone that regulates the biological clock. Early cardiac rehabilitation started in inpatient period is an effective therapy and plays a key role in the management of patients with MI which may improve functional capacity and prevent bed rest complications, so it reduces length of stay in hospital and rate of recurrent myocardial infarction within 90 days of discharge. This is the first prospective study that investigate the effect of early cardiorespiratory rehabilitation combined with melatonin supplementation in patients post AMI treated by primary PCI on sleep quality and functional capacity during hospitalization.

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