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Dexmedetomidine and Vasopressin in Septic Shock - Trial NCT06302998

Access comprehensive clinical trial information for NCT06302998 through Pure Global AI's free database. This Phase 2 trial is sponsored by Mansoura University and is currently Not yet recruiting. The study focuses on Sepsis,Septic Shock. Target enrollment is 260 participants.

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NCT06302998
Phase 2
Not yet recruiting
drug
Trial Details
ClinicalTrials.gov โ€ข NCT06302998
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Dexmedetomidine and Vasopressin in Septic Shock
Dexmedetomidine and Vasopressin (DEX-PRESSIN) for Reducing In-hospital Mortality in Septic Shock Patients: A Protocol for Randomized Controlled Trial (DecatSepsis-2)

Study Focus

Sepsis,Septic Shock

DEX-PRESSIN

Interventional

drug

Sponsor & Location

Mansoura University

Timeline & Enrollment

Phase 2

Jun 01, 2024

Jan 01, 2026

260 participants

Primary Outcome

in-hospital mortality

Summary

Rudiger and Singer suggested strategies for refining adrenergic stress
 (decatecholaminization). They proposed the use of dexmedetomidine and vasopressin to reduce
 the catecholamine load during sepsis. The investigators will use vasopressin as the primary
 vasopressor and a heart rate-calibrated dexmedetomidine infusion in septic shock patients.
 
 The investigators of the current study will use DEXPRESSIN in septic shock patients to
 investigate the effects of decatecholaminization on in-hospital mortality.

ICD-10 Classifications

Septic shock
Other sepsis
Other specified sepsis
Sepsis, unspecified
Sepsis due to other specified staphylococcus

Data Source

ClinicalTrials.gov

NCT06302998

Non-Device Trial