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Indapamide and Chlorthalidone to Reduce Urine Supersaturation for Kidney Stone Prevention - Trial NCT06111885

Access comprehensive clinical trial information for NCT06111885 through Pure Global AI's free database. This Phase 2 trial is sponsored by Insel Gruppe AG, University Hospital Bern and is currently Not yet recruiting. The study focuses on Kidney Stone. Target enrollment is 99 participants.

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NCT06111885
Phase 2
Not yet recruiting
drug
Trial Details
ClinicalTrials.gov โ€ข NCT06111885
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Indapamide and Chlorthalidone to Reduce Urine Supersaturation for Kidney Stone Prevention
Randomized, Double-blind, Crossover Trial Assessing the Efficacy of Indapamide and Chlorthalidone Compared to Hydrochlorothiazide for the Reduction of Urine Supersaturation for Kidney Stone Prevention

Study Focus

Kidney Stone

Indapamide 2.5 MG

Interventional

drug

Sponsor & Location

Insel Gruppe AG, University Hospital Bern

Bern, Switzerland

Timeline & Enrollment

Phase 2

Apr 01, 2024

Jun 01, 2027

99 participants

Primary Outcome

Primary outcome component 1 - calcium oxalate supersaturation in urine,Primary outcome component 2 - calcium phosphate supersaturation in urine

Summary

The aim of this study is to test the efficacy of the two long-acting thiazide-like diuretics
 indapamide and chlorthalidone in reducing urine supersaturation for calcium oxalate and
 calcium phosphate compared to the short-acting thiazide diuretic hydrochlorothiazide for the
 prevention of calcium-containing kidney stones.

ICD-10 Classifications

Kidney dialysis
Small kidney, unspecified
Disorder of kidney and ureter, unspecified
Injury of kidney
Unspecified kidney failure

Data Source

ClinicalTrials.gov

NCT06111885

Non-Device Trial