Efficacy and Safety of Administration of High Levels of Protein to Critically Ill Patients. - Trial NCT05918757

Timeline & Enrollment

Primary Outcome

Change of intensive care unit acquired weakness (ICUAW).

Summary

Critically ill patients are known to develop serious nutritional deterioration during the
 course of their disease. They develop, from the beginning, a multifactorial protein
 malnutrition that relates to a poor clinical course and the development of weakness. Due to
 the increased protein catabolism in this type of patient, there is a rapid degradation of
 muscle mass and loss of functional proteins, and therefore nutritional support is mandatory.
 Indeed, achieving a high protein intake may promote a better evolution of the critically ill
 patient, i.e., maintenance of muscle protein, less deterioration of muscle strength, lower
 Intensive care unit-acquired weakness (ICUAW), lower mortality, decrease in the number of
 infections, decrease in days on mechanical ventilation, and days of hospital stay and in ICU.
 
 The goal of this clinical trial is to compare the appearance and degree of ICUAW in
 critically ill patients receiving invasive mechanical ventilation treated with two different
 doses of protein (1.5 g/kg/day vs.1.0 g/kg/day).

ICD-10 Classifications