Tolerance Assesment of the Usage of an Analgesic Dose of Esketamine for Treatment of Moderate to Intense Pain in an Emergency Departement - Trial NCT05666869
Access comprehensive clinical trial information for NCT05666869 through Pure Global AI's free database. This phase not specified trial is sponsored by Association pour la Formation l'Enseignement et la Recherche du Service de l'Accueil des Urgences and is currently Recruiting. The study focuses on Pain, Acute. Target enrollment is 55 participants.
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Study Focus
Sponsor & Location
Association pour la Formation l'Enseignement et la Recherche du Service de l'Accueil des Urgences
Timeline & Enrollment
N/A
Dec 12, 2022
Sep 01, 2023
Primary Outcome
ESKETAMINE adverse reactions
Summary
KETAMINE has been used for several years in emergency departments for analgesic purposes. Its
 ease of use and its analgesic effect have been demonstrated in several studies.
 
 Nevertheless, this molecule is not devoid of side effects, in particular the very frequent
 occurrence of nausea, vomiting, anxiety, an overall feeling of discomfort and more rarely
 hallucinations, feelings of unreality, or tachycardia.
 
 Recently, ESKETAMINE, used as an anesthetic but also in the USA as an antidepressant, has
 obtained its Marketing Authorization in the management of moderate to severe pain. ESKETAMINE
 corresponds to the S-(-)-KETAMINE enantiomer. Like KETAMINE, it acts as a non-competitive
 antagonist of the N-methyl-D-aspartate (NMDA) receptor but unlike KETAMINE does not interact,
 with the sigma receptors responsible for hallucinations and delusional symptoms. ESKETAMINE
 aimed at anesthetic is about twice as potent as KETAMINE and would also be eliminated more
 quickly.
 
 Studies suggest that at equivalent doses, ESKETAMINE would be better tolerated than the
 KETAMINE usually used in emergency departments.
 
 In this study, the tolerance of ESKETAMINE used at analgesic doses for treatment of moderate
 to severe pain will be assessed in an emergency departement
 
 A wider usage of ESKETAMINE for analgesia purpose in emergency departments is expected, with
 a better tolerance for the patients compared to KETAMINE
ICD-10 Classifications
Data Source
ClinicalTrials.gov
NCT05666869
Non-Device Trial