The Efficacy of Adjunctive Use of Ondansetron in Patients With Sepsis and Septic Shock - Trial NCT05402553
Access comprehensive clinical trial information for NCT05402553 through Pure Global AI's free database. This Phase 1/2 trial is sponsored by Noha Mansour and is currently Recruiting. The study focuses on Sepsis,Septic Shock. Target enrollment is 40 participants.
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Study Focus
Sponsor & Location
Noha Mansour
Mansoura University
Timeline & Enrollment
Phase 1/2
Apr 24, 2022
Oct 01, 2022
Primary Outcome
Sequential organ failure assessment (SOFA score)
Summary
Sepsis is a systemic inflammatory response that has deleterious effects and considered the
 leading cause of death in critically ill patients 1 . One of the hallmarks of severe sepsis
 is the progressive, injurious inflammatory response to infection, mediated by the excessive
 release of inflammatory mediators and consequently, associated with multiple organs damage 2
 . Various studies have demonstrated that adverse outcomes in sepsis patients are closely
 related to the development of myocardial dysfunction 3 . The mortality of sepsis combined
 with cardiac functional insufficiency has increased significantly to 70%-90% 4 . Therefore,
 targeting cardiac insufficiency and heart injury may represent a novel treatment strategy.
 Several reports documented critical involvement of serotonin 5-hydroxytryptamine in the
 pathogenesis of sepsis. The aim of the current study is to evaluate the efficacy of
 ondansetron adjuvant use in patients with sepsis and septic shock.
ICD-10 Classifications
Data Source
ClinicalTrials.gov
NCT05402553
Non-Device Trial