Targeted Fluid Resuscitation in Septic Shock: A Comparative Study between Capillary Refilling Time and Venous to Arterial PCO2 - Trial PACTR202307764415273
Access comprehensive clinical trial information for PACTR202307764415273 through Pure Global AI's free database. This Not Applicable trial is sponsored by Ahmed Ismail and is currently Completed. The study focuses on Infections and Infestations.
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Study Focus
Sponsor & Location
Ahmed Ismail
Ahmed I smail
Timeline & Enrollment
Not Applicable
Sep 21, 2022
Jun 23, 2023
Summary
Adequate cell perfusion as a result of resuscitation in septic shock patients has been considered a critical point in the prognosis of these patients. There have been many parameters that can be followed up to achieve this target as increase the difference between arterial PCO2 and venous PCO2 more than 6 mmHg that has been considered as a signal of tissue hypo perfusion in septic shock patients. Therefore, pursuing to normalize this difference less than 6 mmhg may lead to the risk of fluid overload. Peripheral perfusion, assessed by the capillary refill time (CRT), could be an effective alternative resuscitation target as recently demonstrated by the ANDROMEDA-SHOCK trial. We designed the present randomized controlled trial to address the impact of a CRT-targeted (CRT-T) fluid resuscitation versus the difference of arterial PCO2 to venous PCO2 on fluid balances within 24 h of septic shock diagnosis
ICD-10 Classifications
Data Source
Pan Africa Clinical Trials Registry
PACTR202307764415273
Non-Device Trial