Dexmedetomidine versus Haloperidol efficacy on intra-abdominal pressure, inflammatory response and duration of mechanical ventilation in patients with abdominal sepsis: Comparative Study Controlled by Propofol - Trial PACTR202305682901262

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Summary

The inflammatory response associated with abdom- inal sepsis has grave consequences, including multiple organ dysfunction and death. The immunological effects of stress are mediated by cytokines, which are a group of low-molecular weight proteins which include the interleukins and interferons. They are produced from activated leucocytes, fibroblasts and endothelial cells as an early response to tissue injury and have a major role in mediating immunity and inflammation. Recently, some studies have evaluated the role of dexmedetomidine in sepsis patients with abdominal sepsis, to investigate the optimal sedative to attenuate the inflammatory response by measuring IL-6 and IL-1β serum levels before and after sedation protocol, we aimed to investigate the effects of sedation of patients with abdominal sepsis with dexmedetomidine versus sedation with propofol and effects on inflammatory mediators as IL-6, IL-8 and serum lactate level as primary goal and Intra-abdominal hypertension (IAH) as a secondary goal . The aim of current study is to compare the effects of sedating patients with intraabdominal sepsis with propofol versus dexmedetomidine or haloperidol and its effects on inflammatory response by measuring IL-6 and serum lactate level as primary outecome and effects on intraabdominal pressure , icu hospital stay and mortality as secondary outcomes.

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