Effect and Mechanism of Baitouweng Decoction for Large Intestine Damp-heat Syndrome of Ulcerative Colitis - Trial NCT06421818

Timeline & Enrollment

Primary Outcome

The change of fecal calprotecin.

Summary

Baitouweng Decoction is traditionally used to treat large intestine damp-heat syndrome of
 ulcerative colitis (UC) by oral administration and rectal enema.The project applicant's
 invention of transendoscopic entral tubing (TET) has been used in Baitouweng Decoction for
 the treatment of UC across the whole colon, however, the efficacy have not been reported and
 the underlying mechanism is still unclear. Compared with oral and rectal enema, Baitouweng
 Decoction by colon TET can improve the therapeutic effect by increasing the concentration of
 drugs in the whole colon, which need to be verified. This project will reveal the
 prescription effect and drug-microbiome interaction mechanism of whole colon repeated
 administration of Baitouweng Decoction in the treatment of UC through clinical randomized
 controlled studies, deep intestinal dynamic sampling, integrated analysis of multi-omics and
 TCM prescription metabolomics studies, and provide key scientific basis for the establishment
 of a new approach of whole colon repeated administration of TCM and a new strategy for the
 treatment of UC.

ICD-10 Classifications