A Prospective, Single-arm, Phase II Clinical Trial to Evaluate the Efficacy and Safety of Tafolecimab and Sintilimab Combined With Chemotherapy in Patients With Advanced or Metastatic Driver Gene-negative Non-small Cell Lung Cancer After Failure of First-line Immunotherapy. - Trial NCT06421298
Access comprehensive clinical trial information for NCT06421298 through Pure Global AI's free database. This Phase 2 trial is sponsored by Jinghui Wang and is currently Recruiting. The study focuses on Lung Cancer. Target enrollment is 30 participants.
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Study Focus
Sponsor & Location
Jinghui Wang
Beijing Chest Hospital, Capital Medical University
Timeline & Enrollment
Phase 2
May 17, 2024
May 30, 2027
Primary Outcome
PFS
Summary
The second-line treatment for patients who have progressed after first-line immune checkpoint
 inhibitor therapy, is chemotherapy based on docetaxel and other drugs. The treatment effect
 is limited. The median survival time of them are 6 months. So there is a huge unmet medical
 need.
 
 This study is a Prospective, Single-arm, Phase II Clinical Trial to Evaluate the Efficacy and
 Safety of Tafolecimab and Sintilimab Combined With Chemotherapy in Patients With Advanced or
 Metastatic Driver Gene-negative Non-small Cell Lung Cancer After Failure of First-line
 Immunotherapy. 30 patients will be enrolled.
 
 The main endpoint is PFS๏ผand the secondary endpoint are OS,DCR,DOR,ORR, and so on.
ICD-10 Classifications
Data Source
ClinicalTrials.gov
NCT06421298
Non-Device Trial