Advanced Cardiac Magnetic Resonance Imaging for Assessment of Obstructive Coronary Artery Disease: ADVOCATE-CMR - Trial NCT06419894
Access comprehensive clinical trial information for NCT06419894 through Pure Global AI's free database. This phase not specified trial is sponsored by Amsterdam UMC, location VUmc and is currently Not yet recruiting. The study focuses on Coronary Artery Disease. Target enrollment is 182 participants.
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Study Focus
Observational
Sponsor & Location
Amsterdam UMC, location VUmc
Timeline & Enrollment
N/A
Jun 01, 2024
Jun 01, 2033
Primary Outcome
Diagnostic accuracy of QP CMR (stress myocardial blood flow [MBF], stress relative MBF [rMBF], myocardial perfusion reserve [MPR] and relative MPR [rMPR]) to detect obstructive CAD, as defined by FFR
Summary
Stress perfusion cardiovascular magnetic resonance (CMR) imaging is an established
 non-invasive imaging test for detection of obstructive coronary artery disease (CAD). Fully
 automated quantitative perfusion CMR (QP CMR) is a new technical advancement, which offers
 measurement of myocardial blood flow in CMR. Additionally, recent innovations have introduced
 various contrast-agent-free methods for CAD assessment, such as stress T1 mapping reactivity
 (∆T1) and oxygen-sensitive CMR (OS CMR). These methods might eliminate the necessity for
 contrast administration in clinical practice, simplifying, reducing time, invasiveness and
 costs in evaluating patients with suspected obstructive CAD. The ADVOCATE-CMR study aims to
 validate QP CMR, ∆T1 and OS CMR imaging against invasive fractional flow reserve (FFR) for
 detection of obstructive CAD. The study also aims to head-to-head compare the diagnostic
 accuracy of these CMR techniques with the conventional visual assessment of stress perfusion
 CMR and to correlate them to short- and long-term clinical outcomes.
ICD-10 Classifications
Data Source
ClinicalTrials.gov
NCT06419894
Non-Device Trial