Low-Dose Enoxaparin in Psoriasis - Trial NCT06416566

Timeline & Enrollment

Primary Outcome

Psoriatic Area and Severity Index score

Summary

Rationale:
 
 - Psoriasis is a chronic immune-mediated inflammatory skin disorder where T cells play a
 fundamental role in its pathogenesis.
 
 - Low molecular weight heparin has been reported to exert immunomodulatory effect at small
 doses through inhibition of T cells heparinase enzyme.
 
 - Low molecular weight heparin may have promising results for treatment of psoriasis.
 
 Research question:
 
 - Can low molecular weight heparin be used safely for treatment of psoriasis with good
 outcome?
 
 - Is enoxaparin inhibitory effect on T cell heparinase enzyme responsible for its
 beneficial effect?
 
 Hypothesis:
 
 - Low molecular weight heparin can achieve good results when used at small doses for
 treatment of psoriasis.
 
 - Heparin can exert immunomodulatory effect in psoriasis through inhibition of T cell
 heparinase enzyme.
 
 AIM OF WORK
 
 -The aim of this work is to assess the possible clinical efficacy and safety of low-dose
 enoxaparin in the treatment of psoriasis and to detect if inhibition of heparinase enzyme
 might account for its beneficial therapeutic effect.
 
 Objectives:
 
 - To evaluate safety and efficacy of low molecular weight heparin at small dose for
 treatment of psoriasis.
 
 - Contribute to the ongoing efforts to optimize psoriasis management and improve the lives
 of individuals affected by this chronic condition.

ICD-10 Classifications