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Dose-escalation Study of Ultra-high Dose Ablative Radiosurgery With Immunotherapy for Bulky Metastatic Cancer Patients - Trial NCT06416436

Access comprehensive clinical trial information for NCT06416436 through Pure Global AI's free database. This Phase 1 trial is sponsored by University of Kansas Medical Center and is currently Not yet recruiting. The study focuses on Solid Tumor. Target enrollment is 54 participants.

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NCT06416436
Phase 1
Not yet recruiting
drug
Trial Details
ClinicalTrials.gov โ€ข NCT06416436
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Dose-escalation Study of Ultra-high Dose Ablative Radiosurgery With Immunotherapy for Bulky Metastatic Cancer Patients
Immunotherapy in Combination With Ablative Radiosurgery to Ultra-high DoSes (ICARUS): A Phase I Dose-escalation Radiosurgery Study in Metastatic Cancers

Study Focus

Solid Tumor

Atezolizumab

Interventional

drug

Sponsor & Location

University of Kansas Medical Center

Kansas City, United States of America

Timeline & Enrollment

Phase 1

May 23, 2024

Jul 01, 2027

54 participants

Primary Outcome

Maximum tolerated dose of ultra-high dose Stereotactic Ablative Radiotherapy (SBRT) for 3 different body sites

Summary

The purpose of this study is to determine whether cytoreduction of bulky metastatic disease
 using ultra high dose SBRT in combination with immunotherapy is tolerable and feasible In
 patients who have exhausted SoC treatment options.

ICD-10 Classifications

Malignant neoplasm: Connective and soft tissue, unspecified
Carcinoma in situ, unspecified
Malignant neoplasm: Parametrium
Malignant neoplasm of other connective and soft tissue
Malignant neoplasm: Lip, unspecified, inner aspect

Data Source

ClinicalTrials.gov

NCT06416436

Non-Device Trial