Comparison of Krill and Fish Oil on Clinical and Biochemical Outcomes in Depression - Trial NCT06414226

Timeline & Enrollment

Primary Outcome

Results of Clinical Findings,Results of Clinical Findings

Summary

The Omega-3 polyunsaturated fatty acids (n-3 PUFA), associated with fish oil, has been one of
 the most studied non-pharmacological subjects for its effect on Major Depression Disorder
 (MDD). However, studies comparing the effect of krill oil, on depression are limited, that
 has similar content and different structural forms with fish oil. This study was conducted to
 evaluate the effectiveness of the use of krill and fish oil on clinical effects, biochemical
 outcomes and eating behavior in individuals diagnosed with MDD. It was included 57 adult
 individuals diagnosed with MDD in the psychiatry clinic in this study. Randomization was
 performed after inclusion and exclusion criteria were applied in the study, and participants
 were included in one of three groups. These groups are; 1) krill oil ((n=17),
 (Eicosapentaenoic acid (EPA)=340 mg, Docosahexaenoic acid (DHA)=180 mg)), 2) fish oil
 ((n=17)), (EPA=360 mg, DHA=240 mg), 3) placebo ( (n=16), (EPA=0 mg, DHA=0 mg)). The duration
 of the intervention was 8 weeks. Anthropometric measurements, biochemical outcomes and food
 consumption records of the participants were taken at the beginning and end of the
 intervention, and Hamilton depression rating scale (HDRS), depression anxiety stress-21
 (DASS-21) and food craving questionnaire (FCQ) was applied to the participants. Statistical
 Package for Social Sciences (SPSS) and R studio software were used for statistical analysis
 of the data.

ICD-10 Classifications