EVOC - EVs in Obesity and Cardiometabolic Disease - Trial NCT06408961
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Study Focus
Observational
Sponsor & Location
Massachusetts General Hospital
Timeline & Enrollment
N/A
Jan 05, 2023
Jun 30, 2026
Primary Outcome
What are the contents inside of fat (adipose) tissue derived Extracellular Vesicles (EVs)?,How does the contents of Extracellular Vesicles (EVs) impact cardiac and liver function?,Are changes in Extracellular Vesicle (EV) content related to cardiac function and adiposity with weight loss?
Summary
The goal of this observational study is to research the impact of molecular signals from the
 heart, liver and fat tissue on cardiovascular disease risk, and the presentation of Type II
 Diabetes and diseases that affect the heart, blood vessels and metabolism (Cardiometabolic
 Disease). Specifically, the focus is on the content and function of Extracellular Vesicles
 (EVs), small sacs released from a cell's surface that contain important molecular cargo. The
 main questions it aims to answer are:
 
 1. What molecular cargo do adipose-tissue EVs carry?
 
 2. How do these cargo impact cardiac and hepatic function?
 
 3. Are changes in EV content related to cardiac function and adiposity with weight loss?
 
 Tissue samples from fat tissue and blood samples will be collected from patients receiving
 bariatric weight loss surgery.
ICD-10 Classifications
Data Source
ClinicalTrials.gov
NCT06408961
Non-Device Trial