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Safety and Modulation of Adaptive Immunity by Iscador® Qu Viscum Album Extract in Patients With Advanced, Recurrent or Metastatic Cancers Treated With Immune Checkpoint Inhibitors - Trial NCT06408688

Access comprehensive clinical trial information for NCT06408688 through Pure Global AI's free database. This Phase 4 trial is sponsored by University Hospital, Basel, Switzerland and is currently Not yet recruiting. The study focuses on Advanced Solid Tumor. Target enrollment is 100 participants.

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NCT06408688
Phase 4
Not yet recruiting
drug
Trial Details
ClinicalTrials.govNCT06408688
View on ClinicalTrials.gov
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Safety and Modulation of Adaptive Immunity by Iscador® Qu Viscum Album Extract in Patients With Advanced, Recurrent or Metastatic Cancers Treated With Immune Checkpoint Inhibitors
Safety and Modulation of Adaptive Immunity by Iscador® Qu Viscum Album Extract in Patients With Advanced, Recurrent or Metastatic Cancers Treated With Immune Checkpoint Inhibitors - a Randomized Trial

Study Focus

Advanced Solid Tumor

Immune checkpoint inhibitors plus Iscador® Qu.

Interventional

drug

Sponsor & Location

University Hospital, Basel, Switzerland

Baden,Basel,Liestal,Saint Gallen, Switzerland

Timeline & Enrollment

Phase 4

Jun 01, 2024

Nov 01, 2026

100 participants

Primary Outcome

Percentage of patients with a relative increase in T cell richness or diversity of 20% or more,Percentage of patients with a relative decrease in T cell clonality of 20% or more,Level of T cell richness,Level of T cell diversity,Level of T cell clonality

Summary

The main objective of this study is to test if adding the mistletoe extract Iscador® Qu to
 regular cancer treatment with immune checkpoint inhibitors affects:
 
 - The immune system's ability to fight cancer
 
 - Safety of the treatment
 
 - How well the treatment performs against cancer
 
 - How the patient feels during treatment
 
 Researchers will compare patients treated with immune checkpoint inhibitors plus Iscador® Qu
 with patients treated with imune checkpoint inhibitors only.

ICD-10 Classifications

Carcinoma in situ, unspecified
Malignant neoplasm: Prepuce
Malignant neoplasm: Connective and soft tissue, unspecified
Malignant neoplasm: Parametrium
Malignant neoplasm of other connective and soft tissue

Data Source

ClinicalTrials.gov

NCT06408688

Non-Device Trial