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Nanoliposomal Irinotecan, Oxaliplatin Plus Capecitabine as Conversion Therapy of Locally Advanced Colorectal Cancer - Trial NCT06405139

Access comprehensive clinical trial information for NCT06405139 through Pure Global AI's free database. This Phase 2 trial is sponsored by Cancer Institute and Hospital, Chinese Academy of Medical Sciences and is currently Recruiting. The study focuses on Colorectal Cancer. Target enrollment is 36 participants.

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NCT06405139
Phase 2
Recruiting
drug
Trial Details
ClinicalTrials.gov โ€ข NCT06405139
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Nanoliposomal Irinotecan, Oxaliplatin Plus Capecitabine as Conversion Therapy of Locally Advanced Colorectal Cancer
Phase II Study of Nanoliposomal Irinotecan, Oxaliplatin Plus Capecitabine as Conversion Therapy for Patients With Locally Advanced Colorectal Cancer

Study Focus

Colorectal Cancer

Nanoliposomal Irinotecan, Oxaliplatin plus Capecitabine

Interventional

drug

Sponsor & Location

Cancer Institute and Hospital, Chinese Academy of Medical Sciences

Beijing, China

Timeline & Enrollment

Phase 2

May 06, 2024

Apr 30, 2027

36 participants

Primary Outcome

Organ-sparing R0 Resection Rate

Summary

Neoadjuvant chemotherapy has gained acceptance in treating locally advanced breast cancer,
 esophageal cancer, gastric cancer, and rectal cancer. However, the role of neoadjuvant
 chemotherapy for locally advanced colon cancer is still in the exploratory stage. The
 objective of this study is to explore the efficacy and safety of nanoliposomal irinotecan and
 oxaliplatin combined with capecitabine as a novel conversion therapy for locally advanced
 colorectal cancer patients.

ICD-10 Classifications

Malignant neoplasm of colon
Malignant neoplasm: Descending colon
Malignant neoplasm: Colon, unspecified
Malignant neoplasm: Ascending colon
Malignant neoplasm: Overlapping lesion of colon

Data Source

ClinicalTrials.gov

NCT06405139

Non-Device Trial