The Effects of Auditory Stimulation During Sleep on Brain Networks in Schizophrenia - Trial NCT06386588

Timeline & Enrollment

Primary Outcome

Changes in sleep physiology,Changes in functional connectivity of the hippocampus and thalamus,Changes in hippocampal activation during motor sequence task (MST),Changes in hippocampal microstructural integrity

Summary

In this research study the investigators will use sleep headbands to measure brain rhythms
 and to improve their coordination across brain regions. The headbands will be worn at home
 for multiple nights. On some nights the headbands will play soft sounds at specific times
 during sleep. The investigators are interested in learning whether this timed auditory
 stimulation may be a strategy to improve the coordination of sleep rhythms across brain
 regions, improve network communication, and as a result, improve memory. The investigators
 will study 30 adults aged 18-45 with schizophrenia and 30 demographically matched healthy
 controls. Participants will first have a daytime MRI scan, during which they will complete a
 finger tapping motor sequence task (MST), followed by a week of sleep at home with a sleep
 headband. They will also do the MST at home on two of the nights. On the final day of the
 study, participants will return for a second MRI scan.

ICD-10 Classifications