How Does Cerebellar tDCS Alter Intracortical Inhibition Over Time? - Trial NCT06384495

Timeline & Enrollment

Primary Outcome

stimulus/response curve (S/R Curve),Cortical Silent Period (CSP),Short-interval Intracortical Inhibition (SICI).

Summary

Combining cortical tDCS with behavioral interventions has been shown to have beneficial
 outcomes in individuals post-stroke. However, cerebellar tDCS is a fairly new approach for
 individuals with unilateral cortical stroke and there has not been reports of duration of
 effect of tDCS applied to the cerebellum in this population.
 
 Information gained from this study will serve to fill knowledge gaps on the duration of
 effect of cerebellar tDCS and the effects of polarity.
 
 The purpose of this study is to determine the duration of effect of ventro-lateral cerebellar
 transcranial direct current stimulation (tDCS) in healthy adults through cortical
 excitability (CE), cognitive, language and motor assessment measures. Primary aim: Compare
 baseline CE from left motor cortex of first dorsal interosseous (FDI) and orbicularis oris
 (OO) areas to CE post cerebellar tDCS at 15 minutes, 45 minutes and 75 minutes. Single-pulse
 and paired-pulse transcranial magnetic stimulation (TMS) will be used to measure and compare
 stimulus response curve (S/R curve), cortical silent period (CSP) and short-interval
 intracortical inhibition (SICI) in the hand area and facial area of the left primary motor
 cortex at each time point.
 
 Secondary aim: Compare baseline performance on cognition, motor learning and language tasks
 to performance at 15, 45 and 75 minutes after receiving tDCS. Digit Symbol Substitution Test
 (DSST), Serial Reaction Time Test (SRTT) and Lexical Decision tasks will be presented via a
 computer interface.

ICD-10 Classifications