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Alectinib in Combination With Nivolumab in the Treatment of Recurrent or Refractory HCC Patients Guided With Serum RNase1 and Tumor Expression of PD-L1 - Trial NCT06354387

Access comprehensive clinical trial information for NCT06354387 through Pure Global AI's free database. This Phase 1 trial is sponsored by China Medical University Hospital and is currently Recruiting. The study focuses on Hepatocellular Carcinoma. Target enrollment is 8 participants.

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NCT06354387
Phase 1
Recruiting
drug
Trial Details
ClinicalTrials.gov โ€ข NCT06354387
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Alectinib in Combination With Nivolumab in the Treatment of Recurrent or Refractory HCC Patients Guided With Serum RNase1 and Tumor Expression of PD-L1
A Pilot Study of Alectinib (Alecensa) in Combination With Nivolumab (Opdivo) in the Treatment of Recurrent or Refractory Hepatocellular Carcinoma Patients Guided With Serum Level of RNase1 and Tumor Expression of PD-L1

Study Focus

Hepatocellular Carcinoma

Alectinib (Alecensa), Nivolumab (Opdivo)

Interventional

drug

Sponsor & Location

China Medical University Hospital

Taichung, Taiwan

Timeline & Enrollment

Phase 1

Feb 16, 2022

Jun 01, 2025

8 participants

Primary Outcome

Objective response rate(ORR)

Summary

Hepatocellular carcinoma (HCC) is the fourth most common cause of cancer-related death and
 the second most deadly malignancy in Taiwan. Despite decades' intensive studies, surgery and
 local-regional chemo-embolization, radio-frequency ablation or radiation therapy remain the
 mainstay of HCC treatments.

ICD-10 Classifications

Malignant neoplasm: Hepatoblastoma
Malignant neoplasm: Liver cell carcinoma
Malignant neoplasm: Other specified carcinomas of liver
Malignant neoplasm: Liver, unspecified
Malignant neoplasm: Hepatic flexure

Data Source

ClinicalTrials.gov

NCT06354387

Non-Device Trial