To Evaluate the Dose-response Effects of a Defined Volume of Physical Exercise on the Change of Peripheral Biomarkers, Clinical Response and Brain Connectivity in Parkinson's Disease: a Prospective, Observational, Cohort Pilot Study - Trial NCT06339398
Access comprehensive clinical trial information for NCT06339398 through Pure Global AI's free database. This phase not specified trial is sponsored by Casa di Cura San Raffaele Cassino and is currently Enrolling by invitation. The study focuses on Parkinson Disease. Target enrollment is 30 participants.
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Study Focus
Sponsor & Location
Casa di Cura San Raffaele Cassino
Timeline & Enrollment
N/A
May 01, 2024
May 31, 2028
Primary Outcome
Change in Brain-derived neurotrophic (BDNF) concentration assessed in peripheral blood samples (ng/mL),Change in Brain-derived neurotrophic (BDNF) concentration assessed in peripheral blood samples (ng/mL),Change in Brain-derived neurotrophic (BDNF) concentration assessed in peripheral blood samples (ng/mL)
Summary
This is a prospective, observational, cohort pilot study of standardize volume of aerobic
 exercise on changes in BDNF concentration at 4-weeks of exercise training among Parkinson
 disease patients.
 
 Thirty (N=30) participants will be consecutively enrolled and assigned to 2 groups: 1)
 Extensive Rehabilitation Group (exercise volume: 180 METs-min/week) or 2) Intensive
 Rehabilitation Group (exercise volume: 1350 METs-min/week).
 
 The primary objective is to evaluate the dose-response effects of two different
 rehabilitation settings, characterized by different workload (measured as energy
 expenditure), on blood BDNF levels.
ICD-10 Classifications
Data Source
ClinicalTrials.gov
NCT06339398
Non-Device Trial