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An Organ Preservation Strategies After Chemoradiotherapy Combined With Immunotherapy for Esophageal Cancer (PALACE3). - Trial NCT06339060

Access comprehensive clinical trial information for NCT06339060 through Pure Global AI's free database. This Phase 3 trial is sponsored by Ruijin Hospital and is currently Not yet recruiting. The study focuses on Esophageal Cancer. Target enrollment is 356 participants.

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NCT06339060
Phase 3
Not yet recruiting
combination product
Trial Details
ClinicalTrials.gov โ€ข NCT06339060
View on ClinicalTrials.gov
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An Organ Preservation Strategies After Chemoradiotherapy Combined With Immunotherapy for Esophageal Cancer (PALACE3).
An Organ Preservation Strategies After Chemoradiotherapy Combined With Immunotherapy for Esophageal Cancer vs Cross Therapy.

Study Focus

Esophageal Cancer

Experimental: Arm 1 Organ preservation

Interventional

combination product

Sponsor & Location

Ruijin Hospital

Timeline & Enrollment

Phase 3

May 01, 2024

Mar 01, 2028

356 participants

Primary Outcome

3-year overall survival rate

Summary

Patients with locally advanced esophageal squamous cell carcinoma will randomly assigned to
 receive neoadjuvant chemo-radiotherapy combined with immunotherapy post organ preservation
 strategy (experimental group) or neoadjuvant chemo-radiotherapy followed by surgery (control
 group).
 
 The 3-year overall survival rate is the primary outcome.

ICD-10 Classifications

Carcinoma in situ: Oesophagus
Malignant neoplasm of oesophagus
Malignant neoplasm: Middle third of oesophagus
Malignant neoplasm: Overlapping lesion of oesophagus
Malignant neoplasm: Upper third of oesophagus

Data Source

ClinicalTrials.gov

NCT06339060

Non-Device Trial