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A Study on Tuvusertib (Oral ATR Inhibitor) in Combination With PLX038 (Topo1 Inhibitor) in Patients With Advanced Solid Tumors - Trial NCT06337630

Access comprehensive clinical trial information for NCT06337630 through Pure Global AI's free database. This Phase 1 trial is sponsored by Institut Curie and is currently Not yet recruiting. The study focuses on Solid Tumor. Target enrollment is 92 participants.

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NCT06337630
Phase 1
Not yet recruiting
drug
Trial Details
ClinicalTrials.gov โ€ข NCT06337630
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A Study on Tuvusertib (Oral ATR Inhibitor) in Combination With PLX038 (Topo1 Inhibitor) in Patients With Advanced Solid Tumors
A Phase I Study on Tuvusertib (Oral ATR Inhibitor) in Combination With PLX038 (Topo1 Inhibitor) With Dose Expansion Cohorts in Patients With Advanced Solid Tumors

Study Focus

Solid Tumor

PLX038 + Tuvusertib

Interventional

drug

Sponsor & Location

Institut Curie

Paris,Saint-Cloud, France

Timeline & Enrollment

Phase 1

Jun 15, 2024

Feb 15, 2029

92 participants

Primary Outcome

Dose escalation step : Dose limiting toxicities (DLTs),Expansion cohorts : Best tumor response,Expansion cohorts : Serious Adverse Events (SAEs),Expansion cohorts : Adverse Events (AEs)

Summary

Phase I with a dose finding cohort, followed by expansion cohorts in pre-specified tumor
 types.

ICD-10 Classifications

Malignant neoplasm: Connective and soft tissue, unspecified
Carcinoma in situ, unspecified
Malignant neoplasm: Parametrium
Malignant neoplasm of other connective and soft tissue
Malignant neoplasm: Lip, unspecified, inner aspect

Data Source

ClinicalTrials.gov

NCT06337630

Non-Device Trial