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A Study Comparing Sotorasib With Durvalumab in People With Non-Small Cell Lung Cancer (NSCLC) - Trial NCT06333678

Access comprehensive clinical trial information for NCT06333678 through Pure Global AI's free database. This Phase 2 trial is sponsored by Memorial Sloan Kettering Cancer Center and is currently Recruiting. The study focuses on Non-Small Cell Lung Cancer. Target enrollment is 160 participants.

This page provides complete trial specifications, intervention details, outcomes, and location information. Pure Global AI offers free access to ClinicalTrials.gov data, helping medical device and pharmaceutical companies navigate clinical research efficiently.

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NCT06333678
Phase 2
Recruiting
drug
Trial Details
ClinicalTrials.gov โ€ข NCT06333678
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A Study Comparing Sotorasib With Durvalumab in People With Non-Small Cell Lung Cancer (NSCLC)
A Randomized Phase II Study of Sotorasib Versus Continued Consolidation Durvalumab in Patients With KRAS G12C Mutant Locally Advanced Non-small Cell Lung Cancer (LANSCLC) With Persistent ctDNA Defined Minimal Residual Disease

Study Focus

Durvalumab

Interventional

drug

Sponsor & Location

Memorial Sloan Kettering Cancer Center

Basking Ridge,Middletown,Montvale,Commack,Harrison,New York,Uniondale, United States of America

Timeline & Enrollment

Phase 2

Mar 20, 2024

Mar 01, 2027

160 participants

Primary Outcome

Progression-free survival (PFS)

Summary

In this study, the researchers will look at whether having participants switch from
 durvalumab to sotorasib when they have detectable minimal residual disease (MRD) is an
 effective treatment approach for locally advanced non-small cell lung cancer (LA-NSCLC). The
 researchers will see whether this switch to sotorasib can control LANSCLC longer compared to
 the treatment approach of staying on durvalumab (and not switching to sotorasib).

ICD-10 Classifications

Secondary malignant neoplasm of lung
Malignant neoplasm: Lower lobe, bronchus or lung
Malignant neoplasm: Middle lobe, bronchus or lung
Malignant neoplasm: Bronchus or lung, unspecified
Malignant neoplasm of bronchus and lung

Data Source

ClinicalTrials.gov

NCT06333678

Non-Device Trial