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A Study of DM919 Alone and in Combination With Pembrolizumab in Advanced Solid Tumors - Trial NCT06328673

Access comprehensive clinical trial information for NCT06328673 through Pure Global AI's free database. This Phase 1 trial is sponsored by D2M Biotherapeutics Inc. and is currently Recruiting. The study focuses on Advanced Solid Tumor. Target enrollment is 160 participants.

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NCT06328673
Phase 1
Recruiting
drug
Trial Details
ClinicalTrials.gov โ€ข NCT06328673
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A Study of DM919 Alone and in Combination With Pembrolizumab in Advanced Solid Tumors
A First-in-Human Open-label, Phase 1a / 1b Dose Escalation and Expansion Cohort Study of DM919, a Novel Anti-MICA/B Antibody, as Monotherapy and in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors

Study Focus

Advanced Solid Tumor

DM919

Interventional

drug

Sponsor & Location

D2M Biotherapeutics Inc.

San Antonio, United States of America

Timeline & Enrollment

Phase 1

Mar 01, 2024

Mar 01, 2026

160 participants

Primary Outcome

Number of treatment-emergent events (TEAEs) in Dose Escalation,RDEs or RP2Ds of DM919 alone and in combination with pembrolizumab

Summary

The goal of this clinical trial is to define a safe and effective dose of DM919 for
 participants with solid tumors
 
 The main questions it aims to answer are:
 
 What is the safe and effective dose of DM919 when used alone or in combination with
 pembrolizumab? What cancers can be treated effectively with DM919 alone or in combination
 with pembrolizumab??
 
 Participants will be asked to attend clinic and be given a intravenous infusion of DM919 or
 DM-919 in combination with pembrolizumab. They will have blood tests and other assessments to
 measure whether DM-919 will have the effect on tumors.

ICD-10 Classifications

Carcinoma in situ, unspecified
Malignant neoplasm: Prepuce
Malignant neoplasm: Connective and soft tissue, unspecified
Malignant neoplasm: Parametrium
Malignant neoplasm of other connective and soft tissue

Data Source

ClinicalTrials.gov

NCT06328673

Non-Device Trial