miRNA in Chronic Kidney Diseases - Trial NCT06316284
Access comprehensive clinical trial information for NCT06316284 through Pure Global AI's free database. This phase not specified trial is sponsored by Josip Juraj Strossmayer University of Osijek and is currently Not yet recruiting. The study focuses on Chronic Kidney Diseases. Target enrollment is 90 participants.
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Study Focus
Observational
Sponsor & Location
Josip Juraj Strossmayer University of Osijek
Timeline & Enrollment
N/A
Apr 01, 2024
Dec 31, 2026
Primary Outcome
Systemic microvascular function,Serum level of antixidant enzymesprotein concentration of SOD, CAT and glutathione-peroxidase,Detecton of miRNA of interest
Summary
Oxidative stress and endoplasmic reticulum (ER) stress play a key role in tubular damage in
 both acute kidney injury and chronic kidney disease (CKD). Oxidative stress in the kidneys
 promotes renal vascular remodeling and increases preglomerular resistance. These are key
 elements in hypertension, acute and chronic kidney injury, as well as diabetic nephropathy.
 Chronic renal hypoxia is highlighted as the final common pathway to end-stage renal disease
 (ESRD). MicroRNA molecules (miRNA) also play an important role in these processes. MicroRNAs
 (miRNAs) are regulators of gene expression and play a role in the progression of renal
 ischemia-reperfusion injury. Although the pathophysiological contribution of microRNAs
 (miRNAs) to kidney damage has also been highlighted, the effect of miRNAs on kidney damage
 under conditions of oxidative and ER stress remains understudied.
ICD-10 Classifications
Data Source
ClinicalTrials.gov
NCT06316284
Non-Device Trial