Activity of Chronic Inflammation in PCOS - Trial NCT06300593
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Study Focus
Measurement and comparison of leucocytosis and concentrations of C-reactive protein (CRP), interleukin-1 (IL-1), IL-6, IL-10, Tumor Necrosis Factor (TNF-alpha) in PCOS phenotypes A, B, C and D
Observational
diagnostic test
Sponsor & Location
Jagiellonian University
Timeline & Enrollment
N/A
Jan 15, 2024
Jun 30, 2024
Primary Outcome
Values of inflammation parameters - leukocytosis in peripheral blood in the four PCOS phenotypes,Values of inflammation parameters - C-reactive protein (CRP) in peripheral blood in the four PCOS phenotypes,Values of inflammation parameters - IL-1 in peripheral blood in the four PCOS phenotypes,Values of inflammation parameters - IL-6 in peripheral blood in the four PCOS phenotypes,Values of inflammation parameters - IL-10 in peripheral blood in the four PCOS phenotypes,Values of inflammation parameters - TNF-alpha in peripheral blood in the four PCOS phenotypes
Summary
Chronic inflammation in polycystic ovary syndrome (PCOS) may be the result of dysregulation
 of cytokine production (due to insulin resistance, excess visceral fat and
 hyperandrogenemia), i.e., overproduction of pro-inflammatory factors (e.g. TNF, IL-1, IL-6)
 in relation to anti-inflammatory ones (IL-10). This condition may be an important link
 between obesity and insulin resistance, which is crucial in the etiopathogenesis of the
 syndrome. However, it is not known whether it results from the tendency to accumulate adipose
 tissue or is a feature of the syndrome itself. There is no data indicating the relationship
 between chronic inflammation and the severity of metabolic disorders and the value of ovarian
 reserve in women with various PCOS phenotypes.
ICD-10 Classifications
Data Source
ClinicalTrials.gov
NCT06300593
Non-Device Trial