Beetroot Extract Supplementation Associated With an Exercise Protocol for Chronic Kidney Disease Patients - Trial NCT06286748

Timeline & Enrollment

Primary Outcome

Change individual quality of life,Change physical activity level

Summary

Chronic kidney disease (CKD) patients often present systemic inflammation and oxidative
 stress, resulting in metabolic disorders and high rates of disease-associated cardiovascular
 death. The literature has indicated that dietary control, the use of bioactive compounds, and
 the practice of regular physical exercise are essential for the prevention and management of
 CKD and its complications. In this context, beetroot (Beta vulgaris rubra) deserves attention
 as it is a source of several bioactive compounds, such as nitrate, betaine, and betalain,
 with beneficial effects for CKD patients, including anti-inflammatory, antioxidant effects,
 reduction of blood pressure, and vasodilatory action. The antioxidant and anti-inflammatory
 properties, in addition to their vasodilatory and antihypertensive capacity, can make
 supplementation of beetroot an excellent nutritional strategy to help in the treatment of CKD
 patients. So, this research project will bring contributions to the scientific world,
 providing strategies for application in clinical practice and the care of patients with CKD,
 on the use of beetroot associated with an exercise protocol as a non-pharmacological strategy
 in modulating inflammation, oxidative stress, and improved functional capacity. Furthermore,
 when supplemented hours before physical training, has been identified as an important factor
 in improving performance in these activities. Therefore, this study aims to evaluate the
 effects of supplementation (acute and chronic) of beetroot extract associated with an
 exercise protocol on complications associated with CKD.

ICD-10 Classifications