Effects of Telerehabilitation on Brain Network Connectivity - Trial NCT06278818
Access comprehensive clinical trial information for NCT06278818 through Pure Global AI's free database. This phase not specified trial is sponsored by University of Pavia and is currently Recruiting. The study focuses on Mild Cognitive Impairment. Target enrollment is 110 participants.
This page provides complete trial specifications, intervention details, outcomes, and location information. Pure Global AI offers free access to ClinicalTrials.gov data, helping medical device and pharmaceutical companies navigate clinical research efficiently.
Study Focus
Sponsor & Location
University of Pavia
Timeline & Enrollment
N/A
Dec 07, 2023
Mar 01, 2026
Primary Outcome
Changes in resting-state brain networks functional connectivity after NBTC treatment,Changes in resting-state EEG coherence after NBTC treatment,Changes in resting-state EEG coherence after HomeCore treatment,Changes in resting-state brain networks functional connectivity after SMRT treatment
Summary
The current project aims at assessing the impact of various cognitive telerehabilitation
 approaches on patients with Mild Cognitive Impairment (MCI) associated with neurodegenerative
 diseases, namely Alzheimer's disease (AD) and Parkinson's disease (PD). The study focuses on
 non-pharmacological interventions to maintain patients' residual functionality, limit disease
 progression, and improve quality of life for both patients and their caregivers.
 
 This longitudinal and multicenter study applies innovative cognitive telerehabilitation (TR)
 methods and evaluates their impact on functional parameters obtained with high-density
 electroencephalogram (HD-EEG) and resting-state functional magnetic resonance imaging
 (rsFMRI). The goal is to identify neurophysiological correlates of the effects of three
 different cognitive TR in individuals with MCI due to neurodegenerative conditions.
 
 The study aims to:
 
 - Identify correlations between improvement in cognitive performance and functional brain
 data.
 
 - Use acquired knowledge to develop neurologically guided TR approaches for broader use.
 
 The research will include patients diagnosed with MCI associated with neurodegenerative
 diseases. Primary outcome measures include changes in resting-state brain connectivity
 assessed through HD-EEG and rsFMRI. Secondary outcomes involve the assessment of changes in
 neuropsychological measures, caregiver burden, immediately after rehabilitation and after
 longitudinal follow-up.
 
 The study is designed to last 30 months, with follow-up assessments at three time points. The
 primary outcomes will be evaluated using rsFMRI and HD-EEG instrumental acquisitions, the
 secondary outcomes will be evaluated using clinical assessments and neuropsychological tests.
ICD-10 Classifications
Data Source
ClinicalTrials.gov
NCT06278818
Non-Device Trial