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DZD9008 In Combination With Bevacizumab in Locally Advanced or Metastatic NSCLC Patients With EGFR Mutation (WU-KONG29) - Trial NCT06276283

Access comprehensive clinical trial information for NCT06276283 through Pure Global AI's free database. This Phase 2 trial is sponsored by Dizal Pharmaceuticals and is currently Recruiting. The study focuses on Non-small Cell Lung Cancer. Target enrollment is 60 participants.

This page provides complete trial specifications, intervention details, outcomes, and location information. Pure Global AI offers free access to ClinicalTrials.gov data, helping medical device and pharmaceutical companies navigate clinical research efficiently.

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NCT06276283
Phase 2
Recruiting
drug
Trial Details
ClinicalTrials.gov โ€ข NCT06276283
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DZD9008 In Combination With Bevacizumab in Locally Advanced or Metastatic NSCLC Patients With EGFR Mutation (WU-KONG29)
A Phase II, Single Arm, Multicenter Study to Assess the Safety, Tolerability and Anti-Tumor Efficacy of DZD9008 With Bevacizumab in Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Harboring EGFR Mutations (WU-KONG29)

Study Focus

DZD9008 plus Bevacizumab

Interventional

drug

Sponsor & Location

Dizal Pharmaceuticals

Shanghai, China

Timeline & Enrollment

Phase 2

Feb 15, 2023

Feb 28, 2026

60 participants

Primary Outcome

Part A: 1) Dose Limiting Toxicity (DLT); 2) Treatment-Emergent Adverse Events (TEAEs); TEAEs โ‰ฅCTCAE grade 3; and Serious Adverse Events (SAEs). Part B: 1) TEAEs; TEAEs โ‰ฅCTCAE grade 3; and SAEs.

Summary

This study tests a combination therapy (i.e., DZD9008 plus bevacizumab) in patients with
 advanced NSCLC harboring EGFR mutations who have progressed on or after standard of care,
 which aims to understand whether the combination therapy is safe, how well the combination
 therapy works, and how the body will process DZD9008 when used in combination with
 bevacizumab.

ICD-10 Classifications

Secondary malignant neoplasm of lung
Malignant neoplasm: Lower lobe, bronchus or lung
Malignant neoplasm: Middle lobe, bronchus or lung
Malignant neoplasm: Bronchus or lung, unspecified
Malignant neoplasm of bronchus and lung

Data Source

ClinicalTrials.gov

NCT06276283

Non-Device Trial