Effects of Urolithin A Supplementation on Glucose Metabolism in Healthy Adults 55 = Years Old: A Randomized Triple-Masked Controlled Clinical Trial - Trial NCT06274749

Timeline & Enrollment

Primary Outcome

To determine if urolithin A supplementation will influence insulin secretion in response to oral glucose at 4 and 8 weeks after supplementation.

Summary

Background:
 
 As people age, the cells in the pancreas that produce insulin begin to release less of this
 hormone, and levels of blood glucose (sugar) rise. This can lead to illnesses such as
 diabetes. Urolithin A (UA) is a natural nutritional supplement that may improve how the body
 controls blood glucose.
 
 Objective:
 
 To learn if UA improves levels of insulin and other hormones that help control blood glucose.
 
 Eligibility:
 
 People aged 55 years and older with a body mass index of 27 or higher.
 
 Design:
 
 Participants will have 6 clinic visits over 8 weeks.
 
 Participants will be screened. They will have a physical exam with blood and urine tests and
 a test of their heart function.
 
 UA gelcaps are taken by mouth every morning at home. Half of participants will take UA. The
 other half will take a placebo. The placebo looks like the study drug but does not contain
 any medicine. Participants will not know which they are taking.
 
 Participants will have tests during the study including:
 
 Oral glucose tolerance: Participants will drink a sweet liquid. Blood will be drawn at
 intervals over the next 3 hours.
 
 Continuous glucose monitor: A sensor with a needle that goes just under the skin will be
 placed on the upper arm. Participants will wear this sensor throughout the study.
 
 Exercise. Participants will walk on a treadmill while their heart rate, hearth rhythm, and
 blood pressure are monitored. They will walk in a hallway at normal and fast paces.
 
 Imaging scans of the thigh; scans of the brain are optional....

ICD-10 Classifications