Positive Affect Treatment for Adolescents With Early Life Adversity - Trial NCT06273137
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Study Focus
Sponsor & Location
University of California, Irvine
Timeline & Enrollment
N/A
Feb 03, 2024
Oct 16, 2026
Primary Outcome
Positive affect
Summary
Youth exposed to early life adversity (ELA) are known to be at greater risk for depression
 and suicidality and account for almost half of the youth suffering from psychiatric diseases
 today. Youth exposed to ELA consistently report symptoms of anhedonia as well as dysregulated
 positive affect. The present project will test the efficacy of PAT in a sample of ELA-exposed
 adolescents in order to determine whether PAT increases positive affect, and subsequently
 symptoms of depression. For this pilot, the investigators will recruit 22 adolescents exposed
 to two or more childhood adversities (ACEs) who do not currently have major depressive
 disorder, and randomize them (1:1) to either participate in PAT or a waitlist control
 condition. At study enrollment, then 4-, 8, and 12-months thereafter the investigators will
 measure positive affect and depressive symptoms (including anhedonia). The results of this
 study will be used to inform whether PAT has the potential to prevent major depressive
 episodes among adversity-exposed youth.
ICD-10 Classifications
Data Source
ClinicalTrials.gov
NCT06273137
Non-Device Trial