The Association Between Obstructive Sleep Apnea Severity and Red Blood Cells Indices - Trial NCT06265129

Timeline & Enrollment

Primary Outcome

Red Blood Cells Indices

Summary

Obstructive sleep apnea syndrome (OSAS) is characterized by recurrent episodes of obstructive
 events (apnea and hypopnea) and intermittent hypoxia, which in turn contributes to the
 systemic inflammation that underlies this disease and its consequences (Ryan et al 2009,
 Gileles-Hillel et al 2014). This systemic inflammation leads to endothelial dysfunction,
 which contributes to the pathogenesis of cardiovascular complications in OSAS, in addition to
 the exposure to risk factors, such as male gender, older age, obesity, and lack of exercise
 (Lorenzi Filho et al 2010). Some red blood cells (RBC) and platelets indices have emerged as
 inflammatory biomarkers in various diseases (Tertemiz et al 2016) The severity of OSA is
 significantly associated with increase hematocrit, even after controlling for possible
 confounding variables. However, nocturnal hypoxemia in OSA does not usually lead to clinical
 polycythemia (Choi et al 2006). In patients referred with a clinical diagnosis of OSAS, RDW
 may be a marker for the severity of the condition. As RDW is usually included in a complete
 blood count, it could provide an inexpensive tool for triaging OSAS patients for
 polysomnography evaluation (Sökücü et al 2012). The hematological indices white blood cell
 count (WBC), neutrophil count, lymphocyte count, mean platelet volume (MPV), platelet
 distribution width (PDW), and red blood cell distribution width (RDW) have been proposed as
 alternative markers to those normally used clinically, e.g., interleukin-6 (IL6) and
 C-reactive protein, to evaluate the burden of inflammation in OSAS (Wu et al 2018)

ICD-10 Classifications