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An Exploratory Study on the Treatment of Advanced Solid Tumors by Fast CAR T Cells - Trial NCT06249256

Access comprehensive clinical trial information for NCT06249256 through Pure Global AI's free database. This Phase 1 trial is sponsored by Shanghai Cell Therapy Group Co.,Ltd and is currently Recruiting. The study focuses on Solid Tumor. Target enrollment is 12 participants.

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NCT06249256
Phase 1
Recruiting
biological
Trial Details
ClinicalTrials.gov โ€ข NCT06249256
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An Exploratory Study on the Treatment of Advanced Solid Tumors by Fast CAR T Cells
An Exploratory Study on the Treatment of Advanced Solid Tumors by Secretory PD1 Nanoantibody Targeting Mesothelin Fast CAR T Cells

Study Focus

Solid Tumor

Fast CAR T cells

Interventional

biological

Sponsor & Location

Shanghai Cell Therapy Group Co.,Ltd

Shanghai, China

Timeline & Enrollment

Phase 1

Jun 01, 2023

Dec 31, 2026

12 participants

Primary Outcome

Dose-limiting toxicity(DLT)

Summary

This is a single arm, open-label, dose escalation clinical study to evaluate the safety and
 tolerability of fast autologous mesothelin (MSLN)-targeted chimeric antigen receptor
 (MSLN-CAR) T cells secreting PD-1 nanobodies in patients with solid tumors.

ICD-10 Classifications

Malignant neoplasm: Connective and soft tissue, unspecified
Carcinoma in situ, unspecified
Malignant neoplasm: Parametrium
Malignant neoplasm of other connective and soft tissue
Malignant neoplasm: Lip, unspecified, inner aspect

Data Source

ClinicalTrials.gov

NCT06249256

Non-Device Trial