Impact of Stress on Brain Energy Metabolism - Trial NCT06243783
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Study Focus
Sponsor & Location
Rupert Lanzenberger
Medical University of Vienna
Timeline & Enrollment
N/A
Mar 01, 2024
Feb 29, 2028
Primary Outcome
Stress induced changes in glucose metabolism
Summary
Background: Stress plays an essential role in the pathophysiology of mental disorders.
 However, individual differences in the vulnerability to acute and repeated stress are not
 well understood.
 
 Aim: This work aims to investigate individual differences in glucose metabolism and
 directional connectivity regulating the neuronal stress response.
 
 Design: 68 healthy volunteers will undergo two simultaneous PET/MRI measurements one week
 apart. Participants will complete the Montreal Imaging Stress Test during each measurement
 and in-between. Effects of stress on cognitive performance will be assessed using the n-back
 working memory task. Individual cortisol levels will be acquired to identify stress
 (non)responders as well as (non)habituators.
 
 Implications: This work will characterize differences between stress responders vs.
 non-responders and stress habituators vs. non-habituators in terms of energy metabolism and
 network connectivity. This individual difference in the stress response may represent an
 important cornerstone for future evaluation of patients with mental disorders.
ICD-10 Classifications
Data Source
ClinicalTrials.gov
NCT06243783
Non-Device Trial