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Establishing a New Ultrasound Technique to Improve Assessment of Chronic Kidney Disease. - Trial NCT06159439

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NCT06159439
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Trial Details
ClinicalTrials.gov โ€ข NCT06159439
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DJ Fang

DJ Fang

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Establishing a New Ultrasound Technique to Improve Assessment of Chronic Kidney Disease.
Validation of Contrast Enhanced Ultrasound (CEUS) for the Assessment of Renal Perfusion Using Renal Magnetic Resonance Imaging (MRI) in Chronic Kidney Disease (CKD

Study Focus

Chronic Kidney Diseases

Contrast enhanced ultrasound scan

Interventional

diagnostic test

Sponsor & Location

University of Nottingham

Timeline & Enrollment

N/A

Jan 02, 2024

Feb 02, 2025

10 participants

Primary Outcome

Correlation between ASL-MRI measures of cortical perfusion (ml/ 100g/min) and CEUS measures of renal microvascular blood flow.

Summary

Blood flow to the kidneys is important in the development of kidney diseases. Currently we do
 not have ways of measuring and monitoring kidney blood flow for patients in real-time. This
 is a major barrier to investigation and management of acute kidney injury (AKI) and chronic
 kidney disease (CKD).
 
 Kidney blood flow can be reliably measured using a specialised type of MRI scan, but this is
 expensive and difficult to do in people who are unwell. Contrast-enhanced ultrasound (CEUS)
 is a new technique, which uses a contrast containing microbubbles to measure blood flow. The
 benefits of this method are that it is relatively inexpensive, the contrast agents are not
 kidney-damaging and it can be done at the bedside.
 
 We want to compare contrast enhanced ultrasound against the current best-measure of kidney
 blood flow, to see if it is giving accurate information about kidney blood flow. We will do
 this by doing both MRI and contrast enhanced ultrasound scans in people with chronic kidney
 disease and comparing the results.

ICD-10 Classifications

Chronic kidney disease
Chronic kidney disease, unspecified
Chronic kidney disease, stage 1
Chronic kidney disease, stage 4
Chronic kidney disease, stage 2

Data Source

ClinicalTrials.gov

NCT06159439

Non-Device Trial