Perioperative Hemodynamic and Microcirculatory Physiological Study During TAVI - Trial NCT06154642
Access comprehensive clinical trial information for NCT06154642 through Pure Global AI's free database. This phase not specified trial is sponsored by University Hospital, Geneva and is currently Not yet recruiting. The study focuses on Aortic Valve Stenosis. Target enrollment is 20 participants.
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Study Focus
Determination of arterial compliance using blood pressure waveform analysis
Observational
diagnostic test
Sponsor & Location
University Hospital, Geneva
Timeline & Enrollment
N/A
Jan 02, 2024
Jul 31, 2024
Primary Outcome
Modification in arterial stiffness in large- and small-caliber arteries,Modification in plasma Vascular Endothelium Growth Factor levels,Modification in skin surface temperature gradient,Modification in reactive hyperemia
Summary
The Physiological Study of Haemodynamic and Microcirculatory Evolution before/after
 Transcatheter Aortic Valve Replacement (TAVI) aims to investigate the physiological changes
 induced by the implantation of a prosthetic aortic valve on blood vessels in patients with
 severe aortic stenosis. The hypothesis of the study is that adaptive microcirculatory
 phenomena occur during TAVI implantation. The results of preoperative assessment of
 microcirculatory functional reserve differ according to whether or not organ dysfunction
 occurs after TAVI. There is a progressive adaptation of the microcirculation to the new
 cardiovascular load conditions after TAVI. Early features of this adaptation are associated
 with the occurrence of short- and medium-term complications.
ICD-10 Classifications
Data Source
ClinicalTrials.gov
NCT06154642
Non-Device Trial