Analysis of Urinary, Vaginal and Intestinal Microbiota in Patients With Neurogenic Bladder - Trial NCT06093035

Timeline & Enrollment

Primary Outcome

Characterization of the urinary vaginal and intestinal microbiome

Summary

The neurogenic bladder and bowel are two pathological conditions occurring when damaged
 innervation results in functional alteration of both the bladder and the bowel with a
 clinical presentation that can vary from retention to incontinence often associated with an
 increased risk of infection. Specific microbiological patterns of urinary microbiota are
 associated with states of well-being of the host and play protective and preventive functions
 for numerous urological pathologies such as urinary tract infections, urinary incontinence
 and bladder tumors. What the healthy profile of the bladder microbiota is in subjects with
 neurogenic bladder appears currently poorly reported in literature data. Indeed, in these
 populations different strains of uropathogenic microorganisms, such as E.Coli, Klebsiella,
 Pseudomonas and Enterococcus, are dominant compared to healthy subjects where Lactobacillus
 predominates. The characterization of the gut microbiota in terms of composition can be a key
 tool for understanding the effects that preventive therapeutic and nutritional approaches or
 clinical procedures have on it, subsequently offering the possibility of improving and
 complementing these treatments.
 
 Among human microbiota, the vaginal one, the vaginoma, is among the most studied for its
 correlation with female health status. The core of the vaginal microbiome is Lactobacillus
 which under physiological conditions is represented in particular by Lactobacillus Crispatus,
 Lactobacillus Iners, Lactobacillus Jensenii and Lactobacillus Gasseri. Immune cells and
 related PRRs receptors interact with the microorganisms in the vaginal environment of the
 vaginal environment are the immune cells and the related PRRs receptors thus the close
 relationship between microbiome and immunity as well as between vaginoma and genitourinary
 well-being is now evident. The characterization of the gut, urinary and vaginal microbiota in
 patients with neurogenic bladder secondary to spina bifida and multiple sclerosis can help
 identify a health promoting profile to personalize and characterize the therapeutic
 approach.

ICD-10 Classifications