Augmentation of Interpersonal Psychotherapy With High-Definition Transcranial Direct Current Stimulation for Adolescent Depression - Trial NCT06061653
Access comprehensive clinical trial information for NCT06061653 through Pure Global AI's free database. This phase not specified trial is sponsored by First Affiliated Hospital of Zhejiang University and is currently Recruiting. The study focuses on Depressive Disorder. Target enrollment is 60 participants.
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Study Focus
Sponsor & Location
First Affiliated Hospital of Zhejiang University
Timeline & Enrollment
N/A
Oct 01, 2023
Dec 31, 2025
Primary Outcome
24-item Hamilton Depression Rating Scale,24-item Hamilton Depression Rating Scale,24-item Hamilton Depression Rating Scale,24-item Hamilton Depression Rating Scale,Child Depression Rating Scale-Revised,Child Depression Rating Scale-Revised,Child Depression Rating Scale-Revised,Child Depression Rating Scale-Revised
Summary
Depression is among the most prevalent psychiatric disorders, with an upward trend in its
 manifestation in younger individuals. In contrast to adult depression, adolescent depression
 often presents with longer attack durations, higher recurrence rates, chronicity, and
 elevated disability rates. At present, treatment options for adolescent depression encompass
 pharmacological, physical, and psychological therapies. However, current evidence suggests
 that no antidepressant medication is entirely safe for youths, with only fluoxetine and
 escitalopram being FDA-approved for treating adolescent depression.
 
 Given the weight of interpersonal stressors faced by teenagers, the NICE guidelines recommend
 interpersonal therapy(IPT) as a first-line treatment. A 2020 meta-analysis in the Journal of
 the American Academy of Child and Adolescent Psychiatry reported that interpersonal therapy
 exhibited significantly greater improvements in depression symptoms than cognitive behavioral
 therapy(CBT), although psychotherapeutic effects were modest, achieving a remission rate of
 60%. These results underscore the need for further research to enhance interpersonal
 therapy's effectiveness in treating adolescent depression.
 
 High-Definition Transcranial Direct Current Stimulation (HD-tDCS๏ผis a highly secure
 non-invasive brain stimulation technique that produces sustained effects even after
 stimulation has discontinued, rendering it particularly valuable for therapeutic
 interventions. The proposed study aims to augment a single IPT treatment with HD-tDCS
 stimulation for adolescent depression. By enhancing the excitability of the cerebral cortex,
 HD-tDCS could potentially enhance IPT's therapeutic efficacy in treating adolescent
 depression while facilitating further investigation of its underlying neural circuit
 mechanisms.
ICD-10 Classifications
Data Source
ClinicalTrials.gov
NCT06061653
Non-Device Trial