Molecular Residual Disease (MRD) Guided Adjuvant ThErapy in Renal Cell Carcinoma (RCC) - Trial NCT06005818
Access comprehensive clinical trial information for NCT06005818 through Pure Global AI's free database. This Phase 2 trial is sponsored by University of Alabama at Birmingham and is currently Not yet recruiting. The study focuses on Renal Cell Carcinoma. Target enrollment is 100 participants.
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Study Focus
Sponsor & Location
University of Alabama at Birmingham
Timeline & Enrollment
Phase 2
Dec 01, 2023
Jun 30, 2025
Primary Outcome
Disease Free Survival (DFS) by Investigator's assessment as defined by RECIST 1.1
Summary
The goal of this Clinical Study is to understand the outcomes by informing therapy choice for
 adjuvant treatment in clear cell renal cell carcinoma by using molecular residual disease.
 
 The main question[s] it aims to answer are:
 
 - what is the progression free survival of a cohort of high risk resected RCC patients
 when treated based on MRD
 
 - what is the overall survival of high risk resected RCC patients when treated based on
 MRD
 
 Participants will forgo adjuvant therapy with pembrolizumab if they have no detectable
 molecular residual disease. Participants will continue on with standard of care pembrolizumab
 if they do appear to have molecular residual disease.
ICD-10 Classifications
Data Source
ClinicalTrials.gov
NCT06005818
Non-Device Trial