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Study to Evaluate Safety and Antitumor Activity of Lete-Cel (GSK3377794) in HLA-A2+ Participants With NY-ESO-1 Positive Previously Untreated Advanced (Metastatic or Unresectable) Synovial Sarcoma and Myxoid/Round Cell Liposarcoma - Trial NCT05993299

Access comprehensive clinical trial information for NCT05993299 through Pure Global AI's free database. This Phase 2 trial is sponsored by GlaxoSmithKline and is currently Recruitment Completed. The study focuses on Neoplasms. Target enrollment is 7 participants.

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NCT05993299
Phase 2
Recruitment Completed
drug
Trial Details
ClinicalTrials.gov โ€ข NCT05993299
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Study to Evaluate Safety and Antitumor Activity of Lete-Cel (GSK3377794) in HLA-A2+ Participants With NY-ESO-1 Positive Previously Untreated Advanced (Metastatic or Unresectable) Synovial Sarcoma and Myxoid/Round Cell Liposarcoma
Evaluation of Safety and Antitumor Activity of Lete-Cel (GSK3377794) in HLA-A2+ Participants With NY-ESO-1 Positive Previously Untreated Advanced (Metastatic or Unresectable) Synovial Sarcoma and Myxoid/Round Cell Liposarcoma

Study Focus

Neoplasms

Letetresgene autoleucel

Interventional

drug

Sponsor & Location

GlaxoSmithKline

Pittsburgh,Dallas,Milwaukee,Montreal,Amsterdam,London, Canada,Netherlands,United Kingdom,United States of America

Timeline & Enrollment

Phase 2

Dec 31, 2019

Jul 01, 2024

7 participants

Primary Outcome

Overall Response Rate (ORR)

Summary

This trial will evaluate safety and efficacy of human engineered T-cell therapies, in
 participants with advanced tumors. This trial is a sub study of the Master study NCT03967223.

ICD-10 Classifications

Neoplasms
In situ neoplasms
Personal history of other neoplasms
Benign neoplasms
Malignant neoplasms

Data Source

ClinicalTrials.gov

NCT05993299

Non-Device Trial