CD70 Targeted CAR-T Cells in CD70 Positive Relapsed/Refractory Lymphoma - Trial NCT05948033
Access comprehensive clinical trial information for NCT05948033 through Pure Global AI's free database. This Phase 1/2 trial is sponsored by Chinese PLA General Hospital and is currently Recruiting. The study focuses on Lymphoma. Target enrollment is 30 participants.
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Study Focus
Sponsor & Location
Chinese PLA General Hospital
Timeline & Enrollment
Phase 1/2
Jul 15, 2023
Dec 31, 2026
Primary Outcome
Incidence of treatment related adverse events๏ผAEs๏ผ,Incidence of dose limiting toxicities (DLTs),Maximum tolerated dose (MTD)
Summary
In this single-center, single-arm,prospective, open-label, phase 1/2 study, the safety and
 efficacy of autologous CD70 targeted chimeric antigen receptor modified T (CAR-T) cell
 therapy will be evaluated in patients with CD70 antigen positive Relapsed/Refractory Lymphoma
 . In this clinical trial, at least 12 eligible patients in dose escalation period will be
 enrolled to receive 3 doses of CD70-CAR cell therapy according to the 3+3 principle. In
 dose expansion period, additional at most 21 eligible patients will be enrolled to receive
 CD70-CAR-T cell therapy at dose of recommended phase 2 dose(RP2D).
ICD-10 Classifications
Data Source
ClinicalTrials.gov
NCT05948033
Non-Device Trial