Research on the Biological Mechanism of the Efficacy of Psychotherapy for Depression Based on the fNIRS - Trial NCT05927129
Access comprehensive clinical trial information for NCT05927129 through Pure Global AI's free database. This phase not specified trial is sponsored by First Affiliated Hospital of Zhejiang University and is currently Recruiting. The study focuses on Depressive Disorder. Target enrollment is 90 participants.
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Study Focus
Sponsor & Location
First Affiliated Hospital of Zhejiang University
Timeline & Enrollment
N/A
Jan 01, 2022
Dec 31, 2024
Primary Outcome
Changes in fNIRS (functional Near-Infrared Spectroscopy) after treatment.,Change in remission rate of Hamilton Depression Scale (24-items) (HAM-D24) score after treatment.
Summary
In this project, the investigators will implement medication therapy, psychotherapy, and a
 combination of medication therapy with psychotherapy, specifically utilizing IPT, in patients
 with depression. Simultaneously, the investigators will conduct comprehensive fNIRS
 assessments on all patients to evaluate changes in their brain function and determine the
 level of effectiveness of psychotherapy. The investigators will also employ standardized
 psychological assessments to evaluate patients, allowing for a comparison of the
 effectiveness of fNIRS assessments and providing clarity on the efficacy of psychotherapy in
 patients with depression, as the investigatorsll as the differential efficacy of different
 treatment approaches, and establishing the biological markers of psychotherapy. Additionally,
 the investigators will collect blood samples, cranial magnetic resonance images, and
 electroencephalograms from patients before and after treatment, which will contribute to
 further exploration of treatment mechanisms in the future.
ICD-10 Classifications
Data Source
ClinicalTrials.gov
NCT05927129
Non-Device Trial