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Molecular Imaging of HER2 Expression in Breast Cancer Using [99mTc]Tc-G3-(G3S)3C Before Chemo/Targeted Therapy - Trial NCT05923268

Access comprehensive clinical trial information for NCT05923268 through Pure Global AI's free database. This phase not specified trial is sponsored by Tomsk National Research Medical Center of the Russian Academy of Sciences and is currently Enrolling by invitation. The study focuses on Breast Cancer Female. Target enrollment is 10 participants.

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NCT05923268
Enrolling by invitation
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Trial Details
ClinicalTrials.gov โ€ข NCT05923268
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Molecular Imaging of HER2 Expression in Breast Cancer Using [99mTc]Tc-G3-(G3S)3C Before Chemo/Targeted Therapy
SPECT Imaging of Human Epidermal Growth Factor Receptor 2 (HER2) Expression in Breast Cancer Using Technetium-99m-labelled Designed Ankyrin Repeat Proteins ([99mTc]Tc-G3-(G3S)3C)

Study Focus

Breast Cancer Female

[99mTc]Tc-G3-(G3S)3C

Interventional

drug

Sponsor & Location

Tomsk National Research Medical Center of the Russian Academy of Sciences

Tomsk, Russian Federation

Timeline & Enrollment

N/A

Jun 04, 2023

Jun 15, 2024

10 participants

Primary Outcome

Gamma camera-based whole-body [99mTc]Tc-G3-(G3S)3C uptake value (%),SPECT-based [99mTc]Tc-G3-(G3S)3C uptake value in tumor lesions (counts) [99mTc]Tc-G3-(G3S)3C uptake coinciding with tumor lesions will be assessed using single-photon emission computed tomography and measured in counts,SPECT-based [99mTc]Tc-G3-(G3S)3C background uptake value (counts),Tumor-to-background ratio (SPECT)

Summary

The study should evaluate distribution of [99mTc]Tc-G3-(G3S)3C in patients with primary
 HER2-positive and HER2-negative breast cancer

ICD-10 Classifications

Malignant neoplasm: Breast, unspecified
Malignant neoplasm of breast
Malignant neoplasm of breast
Carcinoma in situ of breast, unspecified
Personal history of malignant neoplasm of breast

Data Source

ClinicalTrials.gov

NCT05923268

Non-Device Trial