Effects of Polyphenols of Pomegranate Fruit Peel Extract on Inflammation and Oxidative Stress in Metabolic Syndrome - Trial NCT05915117
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Study Focus
Polyphenols of pomegranate fruit peel extract (PoPex)
Interventional
dietary supplement
Sponsor & Location
University of Banja Luka
Timeline & Enrollment
N/A
Apr 01, 2023
Aug 20, 2024
Primary Outcome
Change in oxidative stress biomarkers levels: lipid peroxidation index, nitric oxide metabolites, hydrogen peroxide (H2O2), superoxide anion radical (O2-), and glutation (GSH), catalasis(CAT) and superoxid dismutasis(SOD).,Change in proinflammatori parametars:interleukin-6 (IL-6), tumor necrosis factor-ฮฑ (TNF- ฮฑ), high sensitive CRP (hsCRP), leptin, resistin ,vaspin, chemerin ,lipokalin -2 and katepsin,Change in antiinflammatori parametars:interleukin -5 (IL-5) ,interleukin-10(IL-10), interleukin-12 (IL-12) ,adiponectin and omentin
Summary
The purpose of this study is to evaluate the effects of polyphenols of pomegranate fruit peel
 extract compared to placebo on oxidative stress and inflammation in overweight and obese
 subjects with metabolic syndrome.
ICD-10 Classifications
Data Source
ClinicalTrials.gov
NCT05915117
Non-Device Trial