Effect of Modified Cellulose on Colonic Fermentation of Inulin - Trial NCT05911347
Access comprehensive clinical trial information for NCT05911347 through Pure Global AI's free database. This phase not specified trial is sponsored by University of Nottingham and is currently Recruiting. The study focuses on Irritable Bowel Syndrome. Target enrollment is 30 participants.
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Study Focus
Sponsor & Location
University of Nottingham
Timeline & Enrollment
N/A
May 09, 2023
Aug 31, 2023
Primary Outcome
Breath hydrogen
Summary
A 3-way randomised cross-over study to test the hypothesis that combining either psyllium or
 methylcellulose to form a gel incorporating inulin will reduce gas production as compared to
 inulin given with a placebo, maltodextrin. Subjects will attend on 3 separate days separated
 by a minimum of one week an consume one of 3 test meals. Serial breath samples with be
 obtained to measure hydrogen and methane over the next 24 hours. Primary endpoint: Area under
 curve (AUC) from time 0-6 hours (AUC 0-6) of breath hydrogen (ppm.hour) after treatment
 intake. We will also assess whole gut transit time using the blue muffin and correlate breath
 hydrogen production with in vitro fermentation results.
ICD-10 Classifications
Data Source
ClinicalTrials.gov
NCT05911347
Non-Device Trial