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A Study to Find a Suitable Dose of BI 1821736 and Test Whether it Helps People With Advanced Cancer - Trial NCT05839600

Access comprehensive clinical trial information for NCT05839600 through Pure Global AI's free database. This Phase 1 trial is sponsored by Boehringer Ingelheim and is currently Recruiting. The study focuses on Solid Tumors. Target enrollment is 27 participants.

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NCT05839600
Phase 1
Recruiting
drug
Trial Details
ClinicalTrials.gov โ€ข NCT05839600
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A Study to Find a Suitable Dose of BI 1821736 and Test Whether it Helps People With Advanced Cancer
An Open-label, Phase I Dose Escalation and Expansion Trial to Investigate Safety and Efficacy of BI 1821736 in Patients With Advanced Solid Tumors

Study Focus

Solid Tumors

BI 1821736

Interventional

drug

Sponsor & Location

Boehringer Ingelheim

San Antonio, United States of America

Timeline & Enrollment

Phase 1

May 25, 2023

Nov 22, 2025

27 participants

Primary Outcome

Occurrence of Dose Limiting Toxicities (DLTs) in the Maximum Tolerated Dose (MTD) evaluation period

Summary

This study is open to adults with advanced solid tumours. People with solid tumours for whom
 previous treatment was not successful or no treatment exists can take part.
 
 The purpose of this study is to find the highest dose of a medicine called BI 1821736 that
 people with advanced solid tumours can tolerate. BI 1821736 is a type of immunotherapy. It is
 a special virus that kills cancer cells and helps the immune system fight cancer. In this
 study, BI 1821736 is given to humans for the first time.
 
 Participants receive BI 1821736 as an infusion into a vein about every 3 weeks for up to 3
 months. Study doctors regularly check the participants' health and monitor the tumours. The
 doctors also take note of any unwanted effects that could have been caused by BI 1821736.

ICD-10 Classifications

Malignant neoplasm: Connective and soft tissue, unspecified
Malignant neoplasm of other connective and soft tissue
Carcinoma in situ, unspecified
Malignant neoplasms
Malignant neoplasm: Parametrium

Data Source

ClinicalTrials.gov

NCT05839600

Non-Device Trial