Net Transition Initiative: Efficacy of Two Next-generation Nets for Control of Malaria in Cote d'Ivoire - Trial NCT05796193

Timeline & Enrollment

Primary Outcome

malaria case incidence by malaria rapid diagnostic test HRP2/pLDH [pf/pan]

Summary

The investigator plan to conduct a three-arm cluster-randomized control trial which compares
 two next generation of long-lasting Insecticidal Nets (LLINs); Veeralin®LLIN (PBO-py LLIN),
 Interceptor G2 (chlorfenapyr-py LLIN) to a standard py-LLIN in the department of Tiebissou
 Southern Bouake city, central Côte d'Ivoire.
 
 The primary objective of the project is to evaluate the efficacy of chlorfenapyr-pyrethroid
 and piperonyl-butoxide (PBO) synergist-pyrethroid LLINs on malaria case incidence in children
 aged 6 months to 10 years compared to standard pyrethroid-only LLINs. The secondary
 objectives are to evaluate the efficacy of the two intervention LLINs compared to the
 standard LLIN on a) malaria infection prevalence in the general population (both children and
 adults), b) vector density and c) entomological inoculation rate (EIR) (as a proxy for
 malaria transmission). In addition, changes in phenotypic resistance intensity and selection
 for molecular resistance mechanisms at baseline and 12 months post-LLIN distribution, in
 sentinel villages in each treatment arm will be investigate.
 
 It is vital to demonstrate that these next generation LLINs which are becoming the standard
 of care in Sub Saharan AFRICA, are superior to standard py-LLIN in the most extreme
 resistance areas as this is likely where alternative interventions will be most needed to
 keep malaria control on track. The trial will generate the first epidemiological evidence on
 the efficacy of PBO nets compared to py-LLIN in West Africa.

ICD-10 Classifications