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A Companion Diagnostic Study to Develop Circulating Exosomes as Predictive Biomarkers for the Response to Immunotherapy in Renal Cell Carcinoma - Trial NCT05705583

Access comprehensive clinical trial information for NCT05705583 through Pure Global AI's free database. This phase not specified trial is sponsored by Zhejiang Cancer Hospital and is currently Recruiting. The study focuses on Renal Cell Carcinoma. Target enrollment is 100 participants.

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NCT05705583
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Trial Details
ClinicalTrials.gov โ€ข NCT05705583
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A Companion Diagnostic Study to Develop Circulating Exosomes as Predictive Biomarkers for the Response to Immunotherapy in Renal Cell Carcinoma

Study Focus

Renal Cell Carcinoma

Other: Blood and Urine Collection

Observational

other

Sponsor & Location

Zhejiang Cancer Hospital

Hangzhou, China

Timeline & Enrollment

N/A

Jan 01, 2023

Dec 31, 2025

100 participants

Primary Outcome

The correlation between the circulating exosomes levels and the tumor responsiveness

Summary

Immune checkpoint inhibitors targeting PD-1 or PD-L1 have been developed and clinical trials
 showning better response in unselected patients with metastatic renal cell carcinoma (RCC).
 At the moment, no clear biomarker exists to accurately predict anti-PD1/PDL1 RCC
 responsiveness. The objective of this study is to develop and evaluate the utility of
 circulating exosomes as companion diagnostic biomarker for predicting response to
 immunotherapy in patients with RCC.

ICD-10 Classifications

Malignant neoplasm of kidney, except renal pelvis
Malignant neoplasm of renal pelvis
Secondary malignant neoplasm of kidney and renal pelvis
Benign neoplasm: Kidney
Benign neoplasm: Renal pelvis

Data Source

ClinicalTrials.gov

NCT05705583

Non-Device Trial